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Assisted Reproduction

Breaking A Myth – Women Might Not Have Finite Number Of Eggs

While more research is needed, this is potentially extremely significant news:

Scientists have produced strong new evidence challenging one of the most fundamental assumptions in biology: that female mammals, including women, are born with all the eggs they will ever have.

In a provocative set of experiments involving mice, Chinese researchers have shown for the first time that an adult mammal can harbor primitive cells in her ovaries that can become new eggs and produce healthy offspring, they reported Sunday.

Much more research is needed to confirm and explore the findings, but the work raises the tantalizing possibility that it could someday lead to new ways to fight a woman’s biological clock, perhaps by stockpiling her egg-producing cells or by stimulating them to make eggs again.

The findings also could help speed stem cell research by providing scientists with a new source of eggs, which are crucial for producing embryonic stem cell lines tailored to individual patients and diseases but difficult to obtain.

“This is a very big deal,” said Roger Gosden, director of reproductive medicine at Weill Cornell Medical Center in New York, who was not involved in the research, published online by Nature Cell Biology.

Some species remain fertile through their lives, and men produce sperm daily. But for at least half a century the dominant scientific tenet has been that women and all other female mammals are born with all the eggs they will ever have, and that stock is slowly depleted with age. For women, the belief has been that most of their eggs are gone by the time they reach middle age, prompting menopause and leaving them infertile.

Although several studies in recent years have raised questions about that belief, those claims remained highly controversial. The new research marks the first time scientists have obtained cells from an adult mammal that appear capable of producing new eggs and healthy offspring.

“If you are looking to disprove that females cannot make new eggs, this paper proves it. It’s a really significant paper,” said Jonathan Tilly, a professor of obstetrics, gynecology and reproductive biology at Harvard Medical School who published some of the most controversial research suggesting that women remain capable of producing new eggs.


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